Sometimes, a drug that works for one condition can also have benefits for another one because the human body has many intricate mechanisms and processes—for example, Science’s 2023 breakthrough of the year - GLP-1 agonists. When researchers develop a drug, they focus on a specific target, like managing blood sugar in diabetes. But sometimes, these drugs can work on other targets, too. Semaglutide (a GLP-1 agonist), for example, not only boosts insulin production but also reduces appetite and slows digestion, leading to weight loss with some ‘manageable’ side effects. This unexpected benefit opened the door for its approval in obesity treatment. After realising this breakthrough, doctors started prescribing Semaglutide off-label as a weight loss medication. This unexpected benefit opened the door for its approval in obesity treatment. Off-label prescribing: why? Even for approved uses, not every drug works for every patient. Doctors, with their clinical expertise, can sometimes prescrib