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Pineapple Juice : An Excellent Catalyst for Biginelli Reaction

Pineapple is almost everyone's favorite fruit and favorite juice. but not only is it good to consume, its also great for chemical reactions and green chemistry; cleaner ways to make pharmaceutical products.  An efficient and greener synthesis of a series of dihydropyrimidinone (DHPMs) derivatives were accomplished via three-component one-pot cyclocondensation between substituted aryl aldehydes, diketone/ke- toester and urea. This solvent free approach is totally nonpolluting having several advantages such as shorter reaction time, mild reaction conditions, simple workup and reduced environmental impact.